The methods of vibrational microspectroscopy reveals long-term biochemical anomalies within the region of mechanical injury within the rat brain

Abstract Traumatic brain injury (TBI), meaning functional or structural damage which appear as a result of the application external physical force, constitutes main cause death and disability individuals great socioeconomic problem. To search for new therapeutic strategies TBI, better knowledge about posttraumatic pathological changes occurring in is necessary. Therefore present paper Fourier transform infrared microspectroscopy Raman microscopy were used to examine local remote biochemical rat focal cortex injury. The site dorsal part hippocampal formation together with above situated white matter subject study. topographic quantitative analysis followed statistical study using principal component showed significant biomolecular anomalies within lesion but not area cortex. observed intralesional included significantly decreased accumulation lipids their place Also levels compounds containing phosphate carbonyl groups lower comparing surrounding opposite relation was, turn, found bands characteristic proteins cholesterol/cholesterol esters.